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From: michael derrida
Category: 妀珛陓洘
Date: 11/9/2003
Time: 4:32:18 AM
Remote Name: 218.95.161.106
What is MDidea Transresveratrol:Basic Botanical Data and Product Data of MDidea T ransresveratrol.Super Function of Trans-resveratrol as Polygonum Cuspldatum P.E.?
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What is MDidea Transresveratrol:Basic Botanical Data and Product Data of MDid ea Transresveratrol.
[Description]:Polygonum Cuspldatum P.E. Trans-resveratrol;A phenolic product found in both grape skin and wines. Has antifungal, antitumor and antioxidative p roperties. A specific inhibitor of cyclooxygenase每1 (COX每1; ED50 = 15 米M). Als o inhibits the hydroxyperoxidase activity of COX每1 (ED50 = 3.7 米M). Inhibits ph orbol ester每induced free radical formation in HL每60 cells (ED50 = 27 米M) and a cts as an anti每mutagenic agent (ED50 = 15 米M) in TM677 cells treated with DMBA. also best character as antioxidant,and best choice for cosmetics and healthfood a dditives. also many other kind of uses. [Botanical Source]:Polygonum cuspidatum(Polygonum cuspidatum sieb. et zucc; )
[Source Synoms]:The weed Polygon urn cuspidaturn(Polygonum Cuspldatum P.E.);P olygonurn cuspidaturn, known as Hu-Chang and Ko-jo-kon;the roots of Polygonurn cu spidaturn Sieb. et Zucc.;Polygonurn multiflorurn Thumb. ;also named as Reynoutria japonica in Europe. [Plant Part Used]:root & stem
Botanical Origins of Transresveratrol:roots of Polygonurn cuspidatum:
Then,What is Polygonum cuspidatum?Is Polygonum cuspidatum same as Reynoutria japonica?
Botanical Description and Name Identification of Polygonum cuspidatum:
Polygonum cuspidatum was classified as Reynoutria japonica by Houttuyn in 177 7 and as Polygonum cuspidatum by Siebold in 1846. It was not until the early part of the 20th century that these were discovered to be the same plant (Bailey, 199 0). The plant is generally referred to as Polygonum cuspidatum by American author s and as Reynoutria japonica in the United Kingdom and Europe. Recent evidence su ggests that this plant should be reclassified as Fallopia japonica (Bailey, 1990) . Polygonum cuspidatum is an herbaceous perennial which forms large clumps 1-3 meters high. It is fully dioecious and can reproduce by seed and by large rhizom es which may reach a length of 5-6 meters. The stout stems are hollow and bamboo- like, extend from an erect base and are simple or little branched and glabrous wi th thinly membranous sheaths. Leaves are broadly ovate, truncate to cuneate at ba se, abruptly cuspidate, 5-15 cm long, 5-12 cm broad, with petioles 1-3 cm long. G reenish white flowers 2.5-3 mm long, densely arranged in axillary panicles; 3 sty les; 8-10 stamens with longitudinally dehiscing anthers. Fruiting calyx wing-angled, 6-10 mm long. Achenes shiny black-brown, 3-4 mm long, acutely trigonous. Male flowers have branched panicles on upright racemes w ith the distal end of the raceme in the highest position; individual panicles gen erally point up. Female flowers are drooping or decumbent with the distal end in the lowest position; individual panicles are not oriented in a particular directi on. Both male and female flowers possess vestigial organs of the other sex. Polygonum cuspidatum closely resembles Polygonum sachalinense (Reynoutria sa chalinensis), an exotic species native to northern Japan and the Sakhalin Islands (Ohwi, 1965). P. sachalinense can be distinguished primarily by its larger size, greenish flowers and cordate leaves which gradually taper to the tip (Fernald, 1 950). Polygonum cuspidatum is known to hybridize with Polygonum sachalinense and with Fallopia baldschuanica (Bailey, 1985,1988). Hybrids between Polygonum cuspid atum and Polygonum sachalinense have been frequently mistaken for Polygonum cuspi datum in the U.K. (Bailey, 1990).
Basic Content for final products in powder extracts form in stock:
1.Polygonum Cuspldatum P.E. Trans-resveratrol 99%HPLC [Purity&Concentration]:Specification No Less Than 99.1%. Result No Less Than 99.5% Addition:No any cis isomer content.fit for injection,drink,capsule,drop,high grade cosmetics,experiment,etc.
2.Polygonum Cuspldatum P.E. Trans-resveratrol 50~60%HPLC [Purity&Concentration]:Specification No Less Than 50% or 60%. Addition:Emodin Content No more than 0.2%,and could be lowered if required.ot her content as glucoside,protein,dannins,vitamins and minerals from raw material of Polygonum Cuspldatum root. Suggest Application Scope:Fit for drink,capsule,tablet,high grade cosmetics,h ealth food,common antioxidant uses,etc.
3.Analysis Method,Standard Sample Origin,Chemical Name identification,standar d name express,differentiation and Available Quantity of MDidea Transresveratrol.
[Method Abstract]:Sample Ultrasonic Extracted with methanol, separated by HPL C, use standard material of resveratrol as external standard, calculate concentra tion of resveratrol in Sample by External Standard Method.(Note:Method for Analys is Available For direct Bulk Order Buyers.) [Standard Sample Suggest]MDidea Group:Transresveratrol 99.99% (Optional Standard Material Sigma:Transresveratrol 99.99%) [Cas Number]: [510-36-0] [Chemical Name Identification]: 3,5,4'-trihydroxy-trans-stilbene [Differentiation]:MDidea Transresveratrol no any cis isomer content. [Standard Name Express]:[Transresveratrol(3,5,4'-trihydroxy-trans-stilbene)] as Polygonum cuspidatum P.E. [Formula / M.W.]:C14H12O3/228.2 [Solubility]:Solublein diethyl ether, Chloroform,Alcohol ,Acetone, Etc. [Quantity Available]:For Crude Type:50% Concentration: NLT500kgs Monthly. For Pure Type:NLT50kgs Monthly. And MDidea Transresveratrol now become the major standard of transresveratrol from Asia Origin.
----------------------------------------------------------------------- What is MDidea Transresveratrol:Basic Botanical Data and Product Data of MDid ea Transresveratrol. More General and common knowledge of transresveratrol: Narrative History and Origin of Resveratrol. Health Benefits and research of transreveratrol. Mechanism of Transresveratrol as natural antibiotics and cancer inhibitor.
Cancer Chemopreventive Activity and tumor inhibition of Tran-resveratrol(P olygonum Cuspldatum P.E.). Brief Benefits of transresveratrol. Anti-platelet effects of trans-resveratrol from Polygonum Cuspldatum P.E. . Anti-HIV Effects of transresveratrol. The chemistry and biosynthesis of resveratrol. Cosmetic compositions containing resveratrol and retinoids.
More General and common knowledge of transresveratrol: Narrative History and Origin of Resveratrol. Resveratrol is an active component extracted from Huzhang(Polygonum cuspidat um) As early as the 1920's Dr. Johanna Brandt wrote a book proclaiming that grap es cured her of cancer. Since then it has been known that there are several benef icial substances in grapes (wine also of course) that assist in lowering choleste rol, reduce the risk of heart disease and have antioxidant abilities. Transresveratrol (chemical formula 3,5,4'-trihydroxy-trans-stilbene) is main ly found in the Polygonurn cuspidaturn, known as Hu-Chang and Ko-jo-konㄛthe root s of Polygonurn cuspidaturn Sieb. et Zucc.˙Polygonurn multiflorurn Thumb. ) Transresveratrol, (chemical formula 3,5,4'-trihydroxy-trans-stilbene), is fo und in any quantity in the skin of young unripe red grapes or Polygonum Cuspldatu m(some recent evidence suggests the skins of peanuts may be a third source). Poly gonum Cuspldatu produce transresveratrol to protect themselves after exposure to ultraviolet radiation, ozone or certain biologic agents. It functions as a ribonu cleotide reductase inhibitor like Hydrea (Droxia, hydroxyurea), but potentially w ithout the side effects of Hydrea. It should be noted that another chemical exists within the Polygonum Cusplda tum that is 3,5,4'-trihydroxy-cis-stilbene and that it can also be called resvera trol. However the -cis- version is not as active as the -trans- version that we o ffer.
Differentiation of resveratrol and piceid: ↘A■ □B↙
□A■:Transresveratrol(3D Structure,Left) Vs. □B■:Transresveratrol Pictur e(Right).
↘A■ □B↙
□A■R=H:trans-resveratrol; R=Glc:trans-piceid . □B■R=H:cis-resveratrol; R=Glc:cis-piceid.
↘A■ □B↙
----------------------------------------------------------------------------- -------------- Health Benefits of transreveratrol. Mechanism of Transresveratrol as natural antibiotics and cancer inhibitor. Specifically trans-resveratrol can help inhibit all three stages of cancer b y: Inducing quinone reductase activity, an enzyme that is capable of detoxifyin g carcinogens. Inhibiting cyclo-oxygenase, a substance that causes the production of prosta glandins that stimulate tumor growth, suppress the immune system and activate car cinogens. Inducing the expression of nitroblue tetazolium reduction activity, a marker of non-specific acid esterase activity and macrophage formation. Furthermore trans-resveratrol can inhibit the development of cardiovascular disease. This is performed through its ability as an antioxidant to inhibit plate let aggregation and eicosaniod synthesis and its ability to modulate lipoprotein metabolism.
In humans, studies are underway to determine health benefits of resveratrol in cancer and heart disease. Preliminary research results demonstrate that resver atrol may have anti-infective, antioxidant, and anti-inflammatory properties. Acc ording to studies involving cancer-prone mice, resveratrol seems to reduce the oc currence of skin tumors. Additional studies suggest that resveratrol is unique be cause of its ability to battle cancer at all three steps of the cancer process: i nitiation, promotion, and progression. Researchers believe that resveratrol is partially responsible for the choles terol-lowering effects of red wine. Epidemiologic and clinical studies suggest th at high consumption of resveratrol-rich foods may result in reduced cardiovascula r disease risk, lowered total cholesterol, and lowered LDL cholesterol. Resveratr ol's antioxidant properties may again be the mechanism at work in reducing the ox idation of LDL cholesterol. Currently scientists are exploring additional potenti al health benefits of resveratrol. Resveratrol doses for inhibition, (i.e. assistance in the prevention) of can cer and cardiovascular disease are 5mg or 10mg daily. Doses for the treatment of the same are 15mg to 30mg daily.
----------------------------------------------------------------------------- ---------- Cancer Chemopreventive Activity and tumor inhibition of Tran-resveratrol(Pol ygonum Cuspldatum P.E.): Cancer is the largest single cause of death in both men and women, claiming over 6 million lives each year worldwide. Chemoprevention, the prevention of canc er by ingestion of chemical agents that reduce the risk of carcinogenesis (1), is one of the most direct ways to reduce morbidity and mortality. Cancer chemopreve ntive agents include nonsteroidal anti-inflammatory drugs (NSAIDs) such as indome thacin, aspirin, piroxicam, and sulindac, all of which inhibit cyclooxygenase (CO X) . This inhibitory activity is relevant to cancer chemoprevention because COX c atalyzes the conversion of arachidonic acid to pro-inflammatory substances such a s prostaglandins,which can stimulate tumor cell growth and suppress immune survei llance. In addition, COX can activate carcinogens to forms that damage genetic ma terial. The process of chemical carcinogenesis can be divided into three general sta ges, and chemopreventive agents have been categorized according to the stage that they inhibit. Transresveratrol inhibits cellular events associated with tumor initiation, promotion, and progression. As noted above, the compound was identified on the ba sis of its ability to inhibit the cyclooxygenase activity of COX-1 (median effect ive dose ED50 5 15 mM) (Fig. 2A), and this activity correlates with antitumor pro motion. Although its inhibitory activity was less than that of certain NSAIDs, su ch as indomethacin (ED50 5 2.3 mM) (Fig. 2A),it was much greater than that mediat ed by compounds such as aspirin (ED50 5 880mM). Also, unlike indomethacin and mos t other NSAIDs, resveratrol inhibited the hydroperoxidase activity of COX-1 (ED50 5 3.7 mM) Resveratrol-mediated inhibition was specific for the cyclooxygenase activity of COX-1 because there was no discernable activity when oxygen uptake was assess ed with COX-2 (Fig. 2A), an inducible form of the enzyme associated with response s such as inflammation, and inhibition of the hydroperoxidase activity of COX-2 ( ED50 5 85 mM) was greatly reduced relative to the activity observed with COX-1. On the basis of these results, researchers investigated the anti-inflammator y activity of resveratrol. In the carrageenan-induced model of inflammation in ra ts, resveratrol significantly reduced pedal edema both in the acute phase (3 to 7 hours) and in the chronic phase (24 to 144 hours). The edema-suppressing activit y of resveratrol was greater than that of phenylbutazone and was similar to that of indomethacin. Overall, these data demonstrate the potential of resveratrol to inhibit tumo r promotion.
----------------------------------------------------------------------------- -------------- Brief Benefits of transresveratrol Key points: *Protects against free radical injury in vivo *Inhibits hydroxyl and peroxyl radicals *Increases plasma and LDL polyphenols *Inhibits brain monoamine oxidase in vivo * Shown to inhibit the three stages of carcinogenesis and COX-2 activity* * Exhibits anti-inflammatory properties* * Decreases the ※stickiness§ of blood platelets and assures blood vessels r emain open and flexible* * Helps to support proper immune system health* * Shown to inhibit LDL cholesterol oxidation* * Helps to support normal cardiovascular function* * Shown to exhibit phytoestrogen and cardioprotectant properties* * Helps prevent the effects of premature aging*
And trans-resveratrol also act as good inhibitor,please check more: *killing bacteria and antibio--transresveratrol killing bacteria and act as bactericide; *inhibitor of serum triglyceride synthesis--transresveratrol act as serum tr iglyceride synthesis inhibitor; *lipid peroxidation inhibitor--research shows transresveratrol act as good l ipid peroxidation inhibitor; *platelet aggregation inhibitor--transresveratrol show good character of inh ibiting platelet aggregation; *detoxifying carcinogens,carcinogens inhibitor--transresveratrol could act a s antidote of carcinogens,carcinogens inhibitor; *cyclo-oxygenase inhibitor--transresveratrol inhibiting cyclo-oxygenase and act as inhibitor; *prostaglandins inhibitor--transresveratrol act as prostaglandins inhibitor;
*inhibitor of brain monoamine oxidase--transresveratrol proved as brain mono amine oxidase inhibitor; *inhibitor of hydroxyl radicals,hydroxyl radicals inhibitor--transresveratro l show super antioxidant property and inhibiting hydroxyl radicals very effective ly; *inhibitor of peroxyl radicals--transresveratrol proved also widely act as p eroxyl radicals inhibitor but not only hydroxyl radicals inhibitor; *cardioprotection in vivo--transresveratrol also showed act as cardioprotect ion in vivo; *Inhibition of monoamine oxidase A--transresveratrol act as monoamine oxidas e A inhibitor; *inhibitor of malonaldehyde generation --resveratrol act as malonaldehyde ge neration inhibitor; *inhibitor of HIV--transresveratrol also show good character and Anti-HIV Ef fects.
Of course transresveratrol has many other good character and wide uses to be explored, so please read on: in China. It is an antioxidant phenol and a potent vasodilator that inhibits serum triglyceride synthesis, lipid peroxidation, and platelet aggregation. It is extensively used for treatment of blood vessel disease such as atheros clerosis and hyperlipidemia. In addition,it has anti-virus and anti-inflammatory activity, can treat acute microbial infections and viral hepatitis, ect. Transresveratrol reduced oxidative stress in cultured brain cells (PC12 cell s) induced by the addition of Fe2+ and t-butyl hydroperoxide, and increased the a ntioxidant protective effects of vitamins C and E under these same conditions.7 Transresveratrol also protected against free radical injury in cerebral isch emia. Ischemia refers to the obstruction of blood and oxygen flow through an orga n, while restoration of blood and oxygen flow is termed reperfusion. Reperfusion induces more oxidative stress and damage to an organ than ischemia does. In an ischemia-reperfusion rat brain model, resveratrol glycoside decreased levels of free radicals and lipid peroxidation (as demonstrated by a reduction in malondialdehyde production) and increased the antioxidant activities of antioxid ant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. A concentration of 10 milligrams per kilogram body weight had the greatest e ffect.8 Resveratrol increased plasma and LDL polyphenols and enhanced antioxidant activity as judged by decreased plasma peroxides. It also increased lag time and decreased LDL lipid peroxides and lipid peroxidation in the copper-catalyzed per oxidation of LDL conjugated dienes.9 Protykin, a natural extract of trans-resveratrol (20 percent) derived from t he dried rhizome of Polygonum cuspidatum, scavenged both hydroxyl and peroxyl rad icals in vitro, and provided significant cardioprotection in vivo. Supplementatio n of protykin to rats for three weeks dramatically improved postischemic left ven tricular functions and aortic flow as compared to control animals. This was further supported by reduced myocardial (heart) infarct size, as me asured by a computerized TTC staining method, and reduced malondialdehyde formati on, a presumptive marker of oxidative stress. The researchers showed that protyki n demonstrated dramatic cardioprotection, presumably by virtue of its potent free radical scavenging ability.10 Peroxidation of the LDL cholesterol from two healthy volunteers was inhibite d by 81 percent and 70 percent upon the addition of 10 米mol per liter of trans-r esveratrol (2.5 mg per liter). In contrast, 10 米mol per liter of a-tocopherol (n atural vitamin E), which has been associated with a reduced risk of heart disease , had a much lower antioxidant potency than did resveratrol, and inhibited LDL ch olesterol oxidation by only 40 percent and 19 percent.11 Inhibition of monoamine oxidase A was seen to be the prime factor responsibl e for the antioxidant activity of resveratrol. Monoamine oxidase is an enzyme fou nd in most tissues, but especially in the liver and nervous system. It catalyzes the oxidation of a large variety of monoamines, including epinephrine, norepineph rine, and serotonin. Resveratrol and its derivatives induced a significant inhibi tory effect on malonaldehyde generation-a marker of lipid per-oxidation and oxida tive tissue injury-during thrombininduced platelet aggregation. Resveratrol also inhibited brain monoamine oxidase in rats (IC50 of 2 米M), even though lacking the structural features of classic monoamine oxidase inhibito rs. It is thought that inhibiting monoamine oxidase in the brain may be a way to treat depression.12
----------------------------------------------------------------------------- -------------- Anti-platelet effects of trans-resveratrol from Polygonum Cuspldatum P.E. Transresveratrol has been reported to have a variety of anti-inflammatory, an ti-carcinogenic, anti-fungal and anti-platelet effects. Recently, tranresveratrol and other related phenolic compounds including tran s-3,3,5,5-tetrahydroxy-4-methoxystilbene and yuccaols A and C were isolated from the bark of Yucca schidigera by some researchers. They do research to evaluate in vitro the effects of these compounds on plat elet aggregation induced by thrombin and ADP. Pretreatment of platelets with tran sresveratrol or other tested phenolics (1-25 g/ml) slightly reduced platelet aggr egation stimulated by 5 M ADP (P < 0.05) or 10 M ADP (P < 0.005). The comparison of the inhibitory effects of tested compound in thrombin-indu ced platelet aggregation revealed that phenolic showed even stronger antiplatelet actions than resveratrol. These compounds also had an inhibitory effect on the thrombin-induced enzyma tic platelet lipid peroxidation determined as the level of thiobarbituric acid re active substances.
----------------------------------------------------------------------------- -------------- Anti-HIV Effects of transresveratrol. Alonso Heredia, PhD, from the Institute of Human Virology at the University o f Maryland gave an interesting presentation on a new, natural anti-HIV agent.Mate rials used with transresveratrol purchased bulk and low price available from Poly gonum Cuspldatu Root P.E. provided by MDidea Group. I n the scientific literature , this substance has been reported to have anti-cancer, anti-inflammation and ant i-atherosclerotic (hardening of the arteries) benefits. In laboratory studies, transresveratrol was synergistic (enhanced effect by c ombining) with either Videx (ddI, didanosine), Retrovir (AZT, zidovudine) or Hivi d (ddC, zalcitabine). The greatest degree of synergism was with Videx. The agent even reverses Videx resistance when combined with it. Interestingly, when transresveratrol was combined with Videx in the laborator y, the combination had anti-HIV effects on macrophages and even resting lymphocyt es. This latter lymphocyte pool represents a reservoir of HIV that is not eradica ted even after 2-3 of HAART therapy. When transresveratrol and Videx were removed from white cell cultures originally infected with HIV, no viral rebound occurred even after 14 days. Transresveratrol works, in part, by increasing the percentage of cells in the "S" phase of cellular growth.This may decrease the number in the resting phase a nd account for its benefits for the resting pool of lymphocytes.
----------------------------------------------------------------------------- -------------- The chemistry and biosynthesis of resveratrol In 1976, Drs. Langcake and Pryce reported the presence of resveratrol and its derivatives in grapevine tissues. It was discovered at that time that plants produced resveratrol when they wer e under attack by fungi, bacteria, or viruses. This led to the conclusion that resveratrol was a natural protectant to plant s under times of stress, and also led to the beginning of studies to examine whet her resveratrol could be beneficial to humans. Plant antibiotics such as resveratrol are known as phytoalexins. These compounds are the members of the plant kingdom classified as spermatoph ytes. The chemical structure of resveratrol is important because from its structure chemists can determine some properties related to its benefit.
Figure 1 shows the molecular structure of cis and trans-resveratrol and some of their derivatives. The hexagons in the figure are called aromatic rings, and t he OH groups are called hydroxyl groups. When aromatic rings and hydroxyl groups are together the chemical is called a phenol. Since there are more than one of these phenols present, the compounds ar e called polyphenols. Polyphenols are often associated with compounds that are an tioxidants. This is because they can react with radicals to form a more stable molecule; one that is less toxic than the original radical. Figure 2shows the way resveratrol and its derivatives are biosynthesized natu rally in plants. More functions proved to have, such as killing bacteria;good for ladies in me nopause;strenthening pallium controlling ability;and with good calming£¬ ;hypnosising£¬anti-convulsion;adjusting blood pressure;and more other f unctions Transresveratrol also widely used as aroma;health caring food ,nutrition supp lying and daily-chemical industry.
----------------------------------------------------------------------------- -------------- Cosmetic compositions containing resveratrol and retinoids: What is claimed this Cosmetic skin care compositions invented by cosmetic an d skin reseachers from USA suggested as: 1. A cosmetic skin care composition comprising mainly: (i) transresveratrol in an amount of from 0.00001 to 10 wt. %; (ii) a retinoid selected from the group consisting of retinoic acid, retinol , and retinyl acetate; and (iii) a cosmetically acceptable vehicle;wherein said retinoid is present in an amount of about 0.001 to about 10 wt. %. (iv) trans-resveratrol is an essential ingredient of the inventive compositi on.Pure resveratrol and crude form of trans-resveratrol may be obtained commercia lly from MDidea Group or MDidea Exporting Division in large quantities. Cosmetic skin care compositions containing transresveratrol in combination w ith selected retinoids.This invention from some researchers of USA showed mechani sm and suggestions as following: In general, the amount of resveratrol in the inventive compositions is in th e range of from 0.00001 to 10% by weight composition. Preferably in order to lowe r cost and maximize the effect the amount of transresveratrol is in the range of from 0.001% to 5% and most preferably is in the range of from 0.1% to 5%.
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Scintific References: .What is MDidea Transresveratrol:Basic Botanical Data and Product Data of MDi dea Transresveratrol.Super Function of Trans-resveratrol as Polygonum Cuspldatum P.E.?Via Michael Derrida(Repulished by Webbranch MDidea,2003)
Extracts available: Polygonum Cuspldatum P.E. Trans-resveratrol99%HPLC Polygonum Cuspldatum P.E. Trans-resveratrol98%HPLC Polygonum Cuspldatum P.E. Trans-resveratrol95%HPLC Polygonum Cuspldatum P.E. Trans-resveratrol90%HPLC Polygonum Cuspldatum P.E. Trans-resveratrol50%HPLC
======================================================= http://www.mdidea.com/products/herbextract/resveratrol/data.html
--------Cooperation---Welcome------------------- Processor and Deliver: MDidea Group Area: New-Tech Economic Zone,YinChuan City.China General Division Charger:Michael Derrida E-mail: derrida@vip.163.com website; http://www.mdidea.com