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Where to find super Puerarian in high concentration Puerarin97%98%99%HPLC(Origin:

From: ±«ÓãMM  ÎûÎû¹þ¹þ
Category: ÉÌÒµÐÅÏ¢
Date: 8/10/2003
Time: 12:21:26 AM
Remote Name: 61.232.53.1

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Where to find super Puerarian in high concentration Puerarin97%98%99%HPLC(Origin: Pueraria Root--Kudzu Root) and best price?What is Natural Puerarian?Why Use Pueraria Root(Kudzu Root)P.E. from MDidea Group?

Amanuensis&Symbol trace Calligrapher: Michael Derrida

famous processor of natural puerian in high concentration.,JUST contact w ith or check as following: http://www.mdidea.com/products/monomer/mono09.html

Puerarin97%98%99%HPLC(Origin:Pueraria Root--Kudzu Root) ¡ó¡ó¡ó¡ó¡ó¡ó¡ó¡ó¡ó¡ó¡ó¡ó¡ó¡ó¡ó¡ó

Basic Data:

[Chemical Name]:Puerarian [Synoms]: [Botanical Source]:The root of Pueraria thomsanii Benth, or P. lobata Willd. T he Chinese name of this herb is Gegen. [Chemical Formula]: Basic Function: Description: Source: Pueraria lobata (Willd. ) Ohwi. CAS: 3681-99-0 Applicatio ns: Treats angiocardiopathy. A scavenger of reactive oxygen species and inhibito r of LDL oxidation. It has potential effect to prevent atherosclerosis.

What is Natural Puerarian?Why Use Pueraria Root(Kudzu Root)P.E. from MDidea Grou p?

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Organ Affinity: Spleen, Pancreas, Stomach

Effects: Diaphoretic, cooling, dilator of arteries and veins.

Indication: Alcohol craving; "hangover"; treatment of glaucoma; ear ache; hea rt functional problems.

Remarks: Tonic for reduction of alcohol craving; daidzin in kudzu blocks enzy mes which cause alcohol poisoning (hangover); beta-adrenoreceptor antagonist. Pr o tective effects on heart; helps with headaches by the effect of having better bl o od flow to the brain

Original Herb:

The root of Pueraria thomsanii Benth, or P. lobata Willd. The Chinese name of this herb is Gegen.

The root of Pueraria lobata (Willd.) Ohwi or Pueraria thunbergiana, a perenni al deciduous vine, of the family Leguminosae. The kudzu is a fast-growing, woody , somewhat hairy vine that may grow to a length of 18 m in one season. It has lar g e leaves, long racemes with late-blooming reddish purple flowers, and flat, hair y seed pods.

The plant is native to China and Japan, where it was long grown for its edibl e, starchy roots and for a fibre made from its stems. The kudzu was transplanted

to North America with the intention of using it to anchor steep banks of soil an d thereby prevent erosion. The plant has become a rampant weed in parts of the so u theastern United States, however, since it readily spreads over trees and shrubs

as well as exposed soil.

Other uses of the kudzu vine are as a useful fodder crop for livestock, as we ll as an attractive ornamental. Northern winters tend to kill the plant's stems b ut allow the roots to survive.

The root has been used by the Chinese as an herb. In China, the plant is dist ributed everywhere in the south and north of China, picked and dug in spring and

autumn, sliced, dried in the sun and used when raw or after it is baked.

Functions: Expels pathogenic factors from muscles and skin to reduce fever, promotes eru ption, promotes the production of body fluids to quench thirst and invigorates t h e vital functions to relieve diarrhea.

Traditional Chinese Medicine Description: TCM classifies it as a sweet and pu ngent herb with a mild property. It is spasmolytic, antipyretic, secretory, and a nti-diarrheal. It is also thought to induce the eruption of measles at the early

stage. The herb is used in China to treat fever, headache, stiffness of back and

neck, dry mouth in diarrhea or dysentery, and early-stage measles.

Properties: Pungent and sweet in flavor, cool in nature, it is related to the spleen and stomach channels

Chemical Composition: The herb contains the flavonoids daidzin, daidzein, diadzein-4¡¯, 7-diglucosi de, Puerarin-7-xyloside and 4¡¯-6¡¯-O-diacetylpuerarin [1].

4.Pharmacology:

A.Coronary and Cerebral Vasodilatory Effects: The decoction or ethanol extract of Gegen (which contains total flavones, dai dzin, and Puerarin) upon being administered to rats intraperitoneally or subcuta n eously antagonized acute myocardial ischemia induced by pituitrin [2]. The injec t ion of Puerarin caused a marked increase in the coronary flow and a decrease in v ascular resistance. During intravenous injection, the blood flow of the internal

carotid and femoral arteries was also increased, though not as markedly as that i n the coronary vessels. The inability of reserpine to modify the action of the t o tal flavones and Puerarin on coronary circulation indicates a direct relaxant ac t ion on the vascular smooth muscle. Puerarin was more potent than the total flavo n es. Intravenous injection of Puerarin in anesthetized dogs decreased the heart r a te and the total peripheral resistance, slightly decreased the left ventricular w ork, reduced the myocardial oxygen consumption, and increased the myocardial eff i ciency. The cardiac output, however, was not significantly altered. These effect s were beneficial to the maintenance of equilibrium between myocardial oxygen dem a nd and supply [3]. IV injection of extract of Gegen in anesthetized dogs with ac u te myocardial infarction induced by ligation of the anterior descending coronary

artery caused a significant decrease in blood pressure, a slowing of the heart b e at, and a slight decrease in blood flow in the infarcted area. At the same time,

it caused no significant change in the arterial blood oxygen, but significant in c rease in the venous blood oxygen at the coronary sinus and infracted area. The o x ygen utilization and consumption, as well as lactic acid content, in both the no r mal and infarcted areas were markedly decreased. Whereas lactic acid utilization

was markedly increased. These results indicate that Puerarin has excellent effec t s on the metabolism of infarcted myocardium [4]. Injection of total flavones to t he internal carotid artery of anesthetized dogs causes a dose-dependent increase

in the cerebral blood flow and a decrease in cerebral vascular resistance.

B.Hypotensive Effects Pueraria¡¯s total flavones can causes hypertensive dogs and normotensive anes thetized dogs to lower their blood pressure. In hypertensive dogs, the pressure r esponse to norepinephrine and the hypotensive effect of acetylcholine could be a t tenuated by the ethanol extract of Gegen [5]. It has a direct vasodilatory actio n , which decreases the peripheral vascular resistance [3,5]. It can also decrease

the blood catecholamine level [6] and vascular reactivity [5]. This may be the r e ason why it can be effectively used for treating migraine headaches.

C.Inhibition of Platelet Aggregation: ADP-induced rat platelet aggregation was inhibited to different extents by 0. 25, 0.5, and 1.0 mg/ml of Puerarin in vitro, and also intravenous injection. At d oses of 0.5 ¨C 3.0mg/ml, Puerarin also inhibited (in vitro) aggregation of rabbi t and sheep platelets, and those of normal subjects induced by ADP or serotonin. I t can also inhibit secretion of serotonin from platelets [7]. This effect is fav o rable to the prevention and treatment of angina pectoris and myocardial infarcti o n.

D.b-Adrenergic Blocking Effect

E.In various isolated tissues with ¦Â-Adrenergic receptors, this herbal extra ct exhibited different degrees of significant antagonism against the effect of i s oproterenol. This fact suggested that it is a wide-spectrum ¦Â-blocker. The extr a ct of Gegen at doses as low as 15 mg markedly attenuated the stimulant effect of

5 ¦Ìg of isoproterenol on the isolated heart. Whereas tenfold the above dose had

practically no direct inhibitory effect on normal hearts, nor does it influence t he cardiotontic effect of digitalis glycosides. The findings suggest that the he r b has selectivity to the ¦Â1-receptors. The ¦Â2-receptor blocking action was fou n d to be weak because doses up to 150 mg were required in order to antagonize bro n chodilation and peripheral vasodilation induced by isoproterenol [8].

5.Pharmacokinetics:

Orally administered Puerarin was rapidly but incompletely absorbed in rats. I V injection of this substance was found highest in concentration in the kidney, l ower in plasma, liver, and spleen, and lowest in the brain. It was minimally des t royed in the gastrointestinal tract, and it was metabolized in the blood, liver,

and kidneys. Also, it can bind to the proteins of liver, kidneys, lungs and plas m a. The 24-hour urinary and fecal excretion of the oral dose of Puerarin accounte d for 1.85 and 35.7% respectively. The data showed that after administered, it wa s rapidly distributed and eliminated, with low accumulation [9].

6.Toxicity:

Oral administration of dried ethanol extract (10,000 to 20,000 mg/kg daily fo r three days) to mice did not result in any toxic effects. Likewise, no toxic ef f ects were exhibited by the total flavones. The LD50 of the dried ethanol extract

in mice was 2,100¡À120 mg/kg. Oral administration of the ethanol extract (2,000 m g/kg daily) to mice for two months did not cause pathological changes in the sol i d organs. Likewise, administration of the ethanol extract to hypertensive dogs ( 2 ,000 mg/kg daily for 14 days) orally produced no toxic effects either [10].

Cautions on Use:

Reference Materials:

'Shen Nong's Herbal Classic' :

"It is indicated for diabetes, high fever, vomiting and generalized arthralgi a and it lifts yin-qi and removes all toxic substances."

'Other Medical Records of Famous Physicians' :

"It treats febrile diseases, apoplexy and headache, expels pathogenic factors from muscles and skin to reduce fever, induces sweat and opens the interstices o f the skin.

'Methodology of Medication' :

"It is so light and floating as to encourage the stomach-qi to rise, thus pro moting the production of body fluids and expelling pathogenic factors from the m u scles and skin to reduce fever, so it is used to treat diarrhea due to weakness o f the spleen and stomach."

7.Clinical Studies:

A.Headache and Migraine

Symptomatic improvement was achieved in 35 of 42 migraine cases [10]. In hype rtensive patients, it improved the cerebral blood flow, lowered the vascular res i stance, and shortened the influx time in about 50% of the cases [2,10, 11].

B.Hypertension

The total flavones (100 mg daily in two doses) was given for a course of 2-8 weeks to 222 cases of hypertension with pain and stiffness of the neck. 78-90% o f the cases reported relief of neck symptoms. In 90% of the cases remedial effect s appeared after one week of administration, persisting for one to two weeks. In s ome patients there were no relapses during a period of 3 to 9 months after disco n tinuation of therapy. The treatment alleviated symptoms of headache, dizziness, t innitus, and numbness of extremities but did not significantly lower the blood p r essure [2,10].

C.Coronary Disease and Angina Pectoris

191 cases of coronary disease and angina pectoris were treated with Gegen tab let (each tablet contains 10 mg of total flavones), 3-4 tablets three times a da y . This treatment was effective in relief of anginal pain and in improving ECG [2 , 10,12]. Another group of 110 cases of coronary disease were treated with a compo u nd of extract of Puerarin and Crataegi, 90% of them had relief of anginal pain a n d 43% had marked improvement [13].

D.Sudden Deafness at Early Stage

The tablets of the ethanol extract of Gegen (each equivalent to 1.5 grams of crude herb) were used at dose of 1-2 tablets three times a day together with inj e ction of the total flavones 100 mg IM twice daily (and in some cases also supple m ented with vitamin B complex) in order to treat 176 cases for a course of one to

two months, hearing improvement in 79.5% of the cases [2,10, 14].

8.Applications:

<1>. Used for exterior syndromes caused by exopathogens:

Being sweet and pungent in taste, cool in nature and so light as to be able t o rise and disperse and enter the spleen and stomach channels, this herb relieve s exterior syndromes by means of profuse perspiration and expels pathogenic facto r s from muscles and skin to reduce fever, so it is often used together with Chine s e thorowax root (Radix Bupleuri), skullcap root (Radix Scutellariae), dahurian a n gelica root (Radix Angelicae Dahuricae), etc., e.g., Chaige Jieji Tang, for the t reatment of exterior syndromes caused by exopathogens such as fever-causing stag n ation of pathogenic factors, serious fever with light chills, headache with dryn e ss of the nasal cavities, slight thirst with thin and yellow fur; often used in c ombination with ephedra (Herba Ephedrae), cassia twig and herbaceous peony root ( Radix Paeoniae Alba), e.g., Gegen Tang, for exterior syndromes caused by pathoge n ic wind-cold, such as chills with anhidrosis and pains and stiffness of the nape

and back.

<2>. Used for measles without adequate eruption:

This herb relieves exterior syndromes by dispersing exopathogens, expels path ogenic factors from muscles and skin to reduce fever and promotes eruption, so i t can often be used together with skunk bugbane rhizome (Rhizoma Cimicifugae), e. g ., Shengma Gegen Tang, for the treatment of initial attacks of measles, attacks o f exopathogens on the superficies of the body and measles without smooth eruptio n ; it can also be used together with peppermint, great burdock achene (Fructus Ar c tii), jingjie (Herba Schizonepetae), cicada slough, etc.

<3>. Used for thirst due to febrile disease and diabetes due to yin deficienc y:

Being sweet and cool, this herb can encourage stomach-qi to rise while reduci ng fever, with the effect of promoting the production of body fluids to quench t h irst and is often used with common reed rhizome (Rhizoma Phragmitis), Chinese tr i chosanthes (Radix Trichosanthis), windweed rhizome (Rhizoma Anemarrhenae), etc.,

for the treatment of thirst due to febrile diseases and impairment of body fluid s ; largely used in combination with black plums, ophiopogon root (Radix Ophiopogo n is), Chinese trichosanthes (Radix Trichosanthis), dangshen (Radix Codonopsis Pil o sulae), milk vetch root (Radix Astragali seu Hedysari), etc., e.g., Yu Chuan Wan , for the treatment of diabetes due to internal heat.

<4>. Used for diarrhea or dysentery due to pathogenic heat and diarrhea due t o deficiency of the spleen:

This herb can not only clear away and disperse pathogenic heat, but also rais e lucid yang in such a way as to encourage the clear yang-qi of the spleen and s t omach to rise and achieve the effect of relieving diarrhea or dysentery, so it i s often used together with skullcap root (Radix Scutellariae), Chinese goldthread

rhizome (Rhizoma Coptidis) and licorice, e.g., Gegen Qin Lian Tang for the treat m ent of dysentery due to pathogenic heat with undispersed exterior syndromes and t he invasion of pathogenic heat into the interior; often used in combination with

ginseng, tuckahoe (Poria cocos), licorice, etc., e.g., Qiwei Baishu San, for dia r rhea due to deficiency of the spleen.

9.Dosage and Administration: 10-20 g.

Decoct the ingredients for drinking. It should be used when raw to reduce fev er and promote the production of body fluids, while it should be used after baki n g to invigorate vital functions to relieve diarrhea.

Toxic or Side Effects:

10.Modern Researches:

This herb mainly contains flavones, such as daidzein, daidzin, daidzein-4, 7- diglucose glucoside, puerarin, puerarin-7-xyloside, puerarol, xylopuerarin, isof l avonoid glycoside and starch. Kudzu vine root can dilate coronary vessels and ce r ebral blood vessels and increase the blood flow of coronary arteries.

Total flavone of kudzu vine root can reduce the myocardial oxygen consumption and increase the supply of oxygen. Kudzu vine root can directly dilate the bloo d vessels to lower peripheral resistance. It can also reduce blood pressure remar k ably and alleviate the "nape tension" symptom of a patient with a high blood pre s sure in a better way. Puerarin can inhibit the platelet aggregation. Kudzu vine r oot has an extensive blocking effect on beta-receptors. Kudzu vine root also has

an obvious antipyretic effect and can also reduce blood sugar slightly.

Scintific References: References: 1.Where to find super puerian in high concentration and best price?What is Natur al Puerarian?Why Use Pueraria Root(Kudzu Root)P.E. from MDidea Group?

Amanuensis&Symbol trace Calligrapher: Michael Derrida

please check url as following and download directly: http://www.mdidea.com/products/monomer/mono09.html

======================================================= famous processor of natural puerian in high concentration.,JUST contact w ith or check as following: http://www.mdidea.com/products/monomer/mono09.html

any interesting, just transfer an email simply and we would be happy more than j ust help. [Buyer's Guide:info of contact details]:

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