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From: derrida michael E-mail:derrida@vip.163.com
http://www.mdidea.com
Category: 商业信息
Date: 8/4/2003
Time: 9:07:18 PM
Remote Name: 61.232.53.1
where to buy TECA (centella extract)or TTFCA 92~95%HPLC
Author:Michael Derrida
Description Gotu kola is a vine-like plant native to India and Southeast Asia. I n India and Indonesia, gotu kola has a long history of use to promote wound heali ng and treat skin diseases. In Europe, extracts of Centella asiatica are used as drugs for the treatment of wound healing defects. Gotu kola should not be confuse d with Kola nut – which is completely unrelated and is often used in dietary sup plements as a “natural” source of caffeine.
Claims Helps prevent Varicose Veins/Hemorrhoids Helps heal Scars/Burns/Wounds Reduces Skin Inflammation and Skin Wrinkles (smoother skin) Cellulite reduction Increases Energy levels Improves Memory and Circulation Promotes restful Sleep
Theory Gotu kola contains a blend of compounds including at least 3 triterpen es (asiatic acid, madecassic acid and asiaticoside) that appear to have antioxida nt benefits and an ability to stimulate collagen synthesis for tissue regeneratio n.
Scientific Support Perhaps the best data for Gotu kola is shown by its abilit y to improve symptoms of varicose veins, particularly overall discomfort, tiredne ss, and swelling. In human studies, Gotu kola extract (30-180mg/day/4 weeks) lead s to improvements in various measurements of vein function (foot swelling, ankle edema, and fluid leakage from the veins) compared to placebo. Gotu kola appears t o have a generally beneficial effect on connective tissues, where it may improve the structure and function of the connective tissue in the body, keeping veins st ronger and also possibly reducing the symptoms of other connective-tissue disease s. In one animal study, asiatic acid and asiaticoside were the most active of the 3 triterpenes – but all 3 were effective in stimulating collagen synthesis and glycosaminoglycan synthesis. Radiation injury to the skin of Sprague-Dawley rats can be reduced by treatment with madecassol (one of the triterpene compounds in G otu kola) – suggesting a skin regeneration and anti-inflammatory activity
The activity of asiaticoside has been studied in normal as well as delayed-type wound healing. In one animal study (guinea pig punch wounds) topical applications of asiaticoside (0.2% solution) produced a 56% increase in hydroxyproline, 57% i ncrease in tensile strength, increased collagen content and better epithelisation . In streptozotocin diabetic rats, where healing is delayed, topical application of 0.4% solution of asiaticoside over punch wounds increased hydroxyproline conte nt, tensile strength, collagen content and epithelisation thereby facilitating th e healing. In each of these studies, asiaticoside was shown also to be active by the oral route (at 1 mg/kg dose) – suggesting that Gotu kola may work by stimula ting synthesis of collagen and increasing connective tissue strength.
Other studies have indicated an antioxidant effect of asiaticoside. When applied topically (0.2% solution) twice daily for 7 days to skin wounds in rats, results show an increase in both enzymatic and non-enzymatic antioxidants, namely supero xide dismutase (35%), catalase (67%), glutathione peroxidase (49%), vitamin E (77 %) and ascorbic acid (36%) in newly formed tissues. It also results in a several fold decrease in lipid peroxide levels (69%) as measured in terms of thiobarbitur ic acid reactive substance (TBARS). This enhancement of antioxidant levels at an initial stage of healing may be an important contributory factor in the healing p roperties of Gotu kola.
There is no credible evidence supporting the claims of Gotu Kola to benefit ener gy levels, memory enhancement, cellulite reduction, or restful sleep.
Safety Orally, gotu kola appears to be nontoxic and it seldom causes any side effects other than the occasional allergic skin rash. There are some concerns th at gotu kola may be carcinogenic if applied topically to the skin – though this has not appeared as a major concern in animal models of wound healing. There is s ome anecdotal evidence that gotu kola may result in elevated blood sugar levels – and effect that could be of concern to individuals with diabetes.
Value The primary benefits of Gotu kola appear to be an enhancement of wound healing and an improvement in overall vein function (especially for varicose vein s and hemorrhoids). Selling for anywhere between $15 and $30 for a 1-month supply , Gotu kola represents a good value for people who suffer from varicose veins or swollen ankles as well as for anybody recovering from a connective tissue injury (muscle/tendon strain, ligament sprain, skin abrasion, etc…).
Dosage Typical dosage recommendations are in the range of 60-180 mg/day, usua lly consumed in divided doses (20-60mg) 3 times daily for at least 4 weeks. It is important to look for an extract standardized to contain triterpene compounds – typically 30-40% and including asiaticoside, asiatic acid, madecassic acid, and madecassoside (these compounds typically occur at only 1-4% in the whole herb).
Centella Selected Triterpenes 92~95% Assay By HPLC synoms:TECA (centella extract)or TTFCA
Description: Centella Selected Triterpenes 92~95% Assay By HPLC Botanical Source: Centella asiatica Plant part: Dried Root Type of Products Standardized Powder Extract Quantity 1000grams Batch No.: 030205
TEST/OBSERVATION SPECIFICATION RESULT Method Asiaticoside 36-44%Asiatic&Madecassic acid 54-66% 37.66% 57.66% Add the method ,HPLC atlas
Analysis of Centella Selected Triterpenes
一、Asiaticoside
1、Standard preparation：Asiaticoside (C=1.2mg/ml methanol) 2、Sample preparation：Centella Selected Triterpenes(C=1.5mg/ml methanol) 3、Instrument：Waters 515 4、Detection：Waters 2487 5、Wavelength UV 204nm 6、Column:ODS-C18 4.6×250mm 7、Mobile phase：Acetonitrile：Methanol ：Water＝22：28：50 8、Rate：0.8ml/Min
二、Asiatic&Madecassic acid
1、Standard preparation：Asiatic acid(C=1.0mg/ml methanol),Madecassic acid (C=1 .0mg/ml methanol) 2、Sample preparation：Centella Triterpenic Genines(C=1.2mg/ml methanol), 3、Instrument：Waters 515 4、Detection：Waters 2487 5、Wavelength UV 204nm 6、Column:ODS-C18 4.6×250mm 7、Mobile phase：Acetonitrile：Water＝40:60(0.1%HAC) 8、Rate：1.2ml/Min
for more technical details ,JUST contact with or check as following:
Technical Data Sheet Click to Download TDS Click for More
File name:TDScst95.zip
·Download·TDS·Centella Selected Triterpenes 92~95%HPLC
Content Note:Details of Analysis:Description of Centella Selected Triterpenes 92 ~95%HPLC:/Synoms/Ch emical Name/Formula/Molecule Weight/CAS Number/Chemical Index/physical control/M i crobiological control
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We are professional processor of Madecassic acid.and Centella Selected Triterpen es quality: the best. Price:the best you can find.
Samples free and freight collected for the first time transaction , good coopera tion welcome and confirmation soonest in 4 to 6 hours.or even in few minutes.
any interesting, just simply transfer an email to us.
Charger: Dr.Michael Derrida CONTACT http://www.mdidea.com http://www.bio-anti.com/bioanti email:derrida@vip.163.com(auto confirmation for receiption)