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Where to find super emodin?Biologicals and Aplication of Emodin from MDidea Group

From: derrida michael E-mail:derrida@vip.163.com  http://www.mdidea.com
Category: ÉÌÒµÐÅÏ¢
Date: 8/4/2003
Time: 6:18:15 PM
Remote Name: 61.232.53.1

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Where to find super emodin?Biologicals and Aplication of Emodin from MDidea Group ?

Amanuensis&Symbol trace Calligrapher: Michael Derrida

famous processor of natural emodin in high concentration.,JUST contact w ith or check as following: http://www.mdidea.com/products/monomer/mono08.html

Emodin(C15H10O5)95%90%HPLC(Origin:Rheum Root) ¡ó¡ó¡ó¡ó¡ó¡ó¡ó¡ó¡ó¡ó¡ó¡ó¡ó¡ó¡ó¡ó Basic Data:

[Chemical Name]:9, 10-Anthracenedione£¬1£¬3£¬8-trihydroxy-6-methyl [Synoms]:Rhe-umemodin, 3-methyl-1,6,8-trihydroxy-antraquinone, Frangula emodin £¬ Rheum emodin£¬ Archin£¬ Frangulicacid [Botanical Source]:Rheum Palmatum Root [wild plant origin from west of China] [Chemical Formula]:C15H10O5 Basic Function: Effect on the Growth Inhibition and the Mechanism of the Helicobacter pylori E ffetive nd function for cure:ARDS,MODS,MOF and other disease.

Biologicals and Aplication of Emodin from MDidea Group?

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[Biologicals and Aplication of Emodin]:(main effective content:Emodin,Rhein,e tc.)

Anti-aggregant*Anti-cancer*Anti-feedant*Anti-inflammatory*Antiseptic*Antiulce r*Myorelaxant

Effect on the Growth Inhibition and the Mechanism of the Helicobacter pylori Effetive nd function for cure:ARDS,MODS,MOF and other disease.

Emodin is a naturally occurring anthraquinone present in the roots and bark o f numerous plants of the genus Rhamnus. Extracts from the roots, bark, and/or dri ed leaves of buckthorn, senna, cascara, aloe, frangula,and rhubarb have been used as laxatives since ancient times and currently are widely used in the preparatio n of herbal laxative preparations. Anthraquinone glycosides are poorly absorbed f rom the gastrointestinal tract but are cleaved by gut bacteria to produce aglycon es (such as emodin) that are more readily absorbed and are responsible for the pu rgative properties of these preparations. There is extensive exposure to emodin a nd other anthraquinones resulting from the use of herb-based stimulant laxatives. Reports that 1,8-dihydroxyanthraquinone, a commonly used laxative ingredient, ca used tumors in the gastrointestinal tract of rats raised the possibility of an as sociation between colorectal cancer and the use of laxatives containing anthraqui nones.

Because emodin is a hydroxyanthraquinone structurally similar to 1,8-dihydrox yanthraquinone,is present in herbal laxatives,and was reported to be mutagenic in bacteria, it was considered a potential carcinogen and was selected for in-depth evaluation. Male and female F344/N rats and B6C3F1 mice were exposed to emodin ( at least94% pure) in feed for 16 days, 14 weeks, or 2 years.

Genetic toxicology studies were conducted in Salmonella typhimurium, cultured Chinese hamsterovary cells, rat and mouse bone marrow cells, and mouse periphera l blood erythrocytes.

Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-B act ivation, IB degradation, and expression of cell surface adhesion proteins in huma n vascular endothelial cells

Most inflammatory agents activate nuclear transcription factor-B (NF-B) which results in expression of genes for cytokines, adhesion molecules, and enzymes in volved in amplification and perpetuation of inflammation. Emodin (3-methyl-1,6,8- trihydroxyanthraquinone) is an active component from the roots of Polygonum cuspi datum that has been reported to exhibit antiinflammatory properties but the mecha nism is not known. In the present study we investigated the effects of emodin on the activation of NF-B in human umbelical vein endothelial cells (EC). Treatment of EC with TNF activated NF-B; preincubation with emodin inhibited this activatio n in a dose- and time-dependent manner. Emodin did not chemically modify NF-B sub units but rather inhibited degradation of IB, an inhibitory subunit of NF-B. Sinc e the promoter regions of ICAM-1, VCAM-1, and ELAM-1 contain NF-B binding sites a nd these adhesion molecules are involved in the attachment of leukocytes to EC, t he effect of emodin on the adhesion of monocytes to EC and the expression of thes e adhesion molecules was also studied. Treatment of EC with TNF for 6 h increased the adhesion of monocytes to EC, which correlated with increases in cell surface expression of ICAM-1, VCAM-1 and ELAM-1. Pretreatment of EC for 1 h with emodin inhibited both monocyte-EC attachment and expression of ICAM-1, ELAM-1 and VCAM-1 .

These results indicate that emodin is a potent inhibitor of NF-B activation a nd expression of adhesion molecules and thus could be useful in treating various inflammatory diseases.

Scintific References: References: 1.Application and Function of Wild Original Rheum Palmatum Root From China? by Michael Derrida

Amanuensis&Symbol trace Calligrapher: Michael Derrida

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======================================================= famous processor of natural emodin in high concentration.,JUST contact w ith or check as following: http://www.mdidea.com/products/monomer/mono08.html

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