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Resveratrol-- Mechanism of action of resveratrol

From: michael
Category: 斌匍佚連
Date: 5/6/2003
Time: 8:34:37 PM
Remote Name: 61.232.53.1

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Resveratrol-- Mechanism of action of resveratrol

Michael Derrida

The previous chapters have illustrated the diverse protective abilities of the n ovel phyto-pharmaceutical known as resveratrol against a broad spectrum of degen e rative diseases and dysfunctions. The following are major mechanistic pathways o f cytoprotection by this novel phytoalexin. Resveratrol:

*inhibits hydroxyl and peroxyl radicals

*induces Phase Il-drug-metabolizing enzymes and potentiates cancer anti-initiati on activity

*mediates anti-inflammatory effects and inhibits cyclooxygenase (COX) and hydrop eroxidase functions

*induces cancer antipromotion activity and potentiates cancer antiprogression ac tivity

*induces human promyelocytic leukemia cell differentiation

*induces carcinogen detoxification by inducing quaninone reductase activity

*inhibits ribonucleotide reductase, cyclooxygenase, cytochrome P450 1A1, DNA pol ymerase, and NADH:ubiquinone oxireductase enzyme activities. This ability to inh i bit these key enzymes explains resveratrol's antimutagenic, antiproliferative, a n d anti-carcinogenic potential.

*regulates nuclear transcription factor, NF-??, at the level of nuclear transloc ation

*inhibits brain monoamine oxidase in vivo

*enhances collagen synthesis

*functions as a novel phytoestrogen

*inhibits the expression of adhesion molecules ICAM-1 and VCAM-I.

Details pls check at http://www.mdidea.com/products/herbextract/resveratrol/data.html

Synoms of plant: the weed Polygon urn cuspidaturn(Polygonum Cuspldatum P.E.) Polygonurn cuspidaturn, known as Hu-Chang and Ko-jo-kon the roots of Polygonurn cuspidaturn Sieb. et Zucc. Polygonurn multiflorurn Thumb.

[Series of Trans-resveratrol]: spec. available on sale: Polygonum Cuspldatum P.E. Resveratrol>50%Assay By HPLC Resveratrol>90%Assay By HPLC Resveratrol>95%Assay By HPLC Resveratrol>98%Assay By HPLC

content of transresveratrol>80%

Description:3',4',5-Trihydroxystlbene;C14H12O3;

Cas Number ; 510-36-0 Molecular formula : C14H12O3 M.W. : 228.2

Assayed by : HPLC using MDidea trans-Resveratrol 99% as compared substance.

[Packing& Terms]: Type of Products:Standard Extract Powder Price: Most competitive and confirm ASAP. Packing: Aluminum Foil Bag and one Plastic-bag Inside. Standard Drums Outside: N.W 25kgs G.W.28kgs. I.D.40cm〜H45cm Certificate of analysis(COA):available and transfered for ref. just contact with ease and transfer a mail: derrida@vip.163.com

\\\\\\\\\\\\\\\\\\ Technical Data Sheet Click to Download TDS Click for More ,Download,TDS,Transresveratrol99%HPLC http://www.bio-anti.com/download/openfile.asp?id=34&filename=http://www.bio-anti.com/form/res/tdsres99.zip

,Download,TDS,Transresveratrol98%HPLC http://www.bio-anti.com/download/openfile.asp?id=35&filename=http://www.bio-anti.com/form/res/tdsres98.zip

,Download,TDS,Transresveratrol50%HPLC http://www.bio-anti.com/download/openfile.asp?id=36&filename=http://www.bio-anti.com/form/res/tdsres50.zip

Material Safety Data Sheet Click to Download MSDS Click for More ,Download,MSDS,Transresveratrol

http://www.bio-anti.com/download/openfile.asp?id=37&filename=http://www.bio-anti.com/form/res/msdsres.zip

========================================== [Buyer's Guide:info of contact details]:

Manufacture and Supplier: MDidea Charger:MR. Derrida Michael Quality: The Best Price:Most Competitive Exporter Division De MDidea:Professional L'Extrait de Plant Pour recevoir votre commande, contactez-nous : Delegate/Charger:Mr. Michael Derrida Par e-mail derrida@vip.163.com

Par web(Professional L'Extrait de Plant): http://www.mdidea.com

Par web(Standard Material Professional):http://www.materialstandard.com

Par web(NaturalAntioxidant Professional): http://www.bio-anti.com  Par web(Oil-Antioxidant Professional): http://www.oil-antioxidant.com 

=================================================

References

1. Gehm BD, McAndrews JM, Chien PY, et al. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Natl Aca d Sci U S A. 1997;94:14138-14143.

2. Goldberg DM. More on antioxidant activity of resveratrol in red wine [letter] . Clin Chem. 1996;42:113-114.

3. Siemann EH, Creasy LL. Concentration of the phytoalexin resveratrol in wine. Am J Enol Vitic. 1992;43:49-52.

4. Kopp P. Resveratrol, a phytoestrogen found in red wine. A possible explanatio n for the conundrum of the 'French paradox'? Eur J Endocrinol. 1998;138:619-620.

5. Rotondo S, Rajtar G, Manarini S, et al. Effect of trans-resveratrol, a natura l polyphenolic compound, on human polymorphonuclear leukocyte function. Br J Pha r macol. 1998;123:1691-1699.

6. Turrens JF, Lariccia J, Nair MG. Resveratrol has no effect on lipoprotein pro file and does not prevent peroxidation of serum lipids in normal rats. Free Radi c Res. 1997;27:557-562.

7. Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulato rs of platelet aggregation in healthy human subjects. Clin Chim Acta. 1996;246:1 6 3-182.

8. Wilson T, Knight TJ, Beitz DC, et al. Resveratrol promotes atherosclerosis in hypercholesterolemic rabbits. Life Sci. 1996;59:PL15-PL21.

9. Jang M, Cai L, Udeani GO, et al. Cancer chemopreventive activity of resveratr ol, a natural product derived from grapes. Science. 1997;275:218-220.

10. Mgbonyebi OP, Russo J, Russo IH. Antiproliferative effect of synthetic resve ratrol on human breast epithelial cells. Int J Oncol. 1998;12:865-869.

11. Subbaramaiah K, Chung WJ, Michaluart P, et al. Resveratrol inhibits cyclooxy genase-2 transcription and activity in phorbol ester-treated human mammary epith e lial cells. J Biol Chem. 1998;273:21875-21882..

12. Clement MV, Hirpara JL, Chawdhury SH, et al. Chemopreventive agent resveratr ol, a natural product derived from grapes, triggers CD95 signaling-dependent apo p tosis in human tumor cells. Blood. 1998;92:996-1002.

13. Johnson JL, Maddipati KR. Paradoxical effects of resveratrol on the two pros taglandin H synthases. Prostaglandins Other Lipid Mediat. 1998;56:131-143.

14. ElAttar TM, Virji AS. Modulating effect of resveratrol and quercetin on oral cancer cell growth and proliferation. Anticancer Drugs. 1999;10:187-193.

15. Gehm BD, McAndrews JM, Chien PY, et al. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Natl Ac a d Sci U S A. 1997;94:14138-14143.


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